April 23, 2013 -
Charitable Trust becomes Lead Sponsor in Canine Health Foundation Bloat Initiative
Clyde reported that the AKC 2013 Bloat Initiative is a collaborative fundraising project by the AKC Canine Health Foundation to reach out for Bloat research proposals. At this point nine pre-proposals have been received.
They are as follows:
· Effect of diet, water ingestion, hyperglycemia, and hyperinsulinemia on the gastric emptying rate of dogs
· Genomic and Environmental Influences on Bloat in German Shepherd Dogs
· The Immunotype / Gut Microbiome Relationship: A Possible Cause and Predictor of Canine Bloat
· Inherited gastric dysrhythmia predisposes large-breed dogs to gastric-dilatation volvulus (GDV)
· Characterization of serum cytokine concentrations in a clinical cohort of dogs with gastric dilation volvulus
· Application of genomic and molecular methods to understand the pathophysiology of gastric dilatation and volvulus in purebred dogs; A systems biology approach
· Evaluating the gastrointestinal microbiome in dogs with gastric dilatation and volvulus
· Pathogenesis of Canine Acute Gastric Dilatation with Volvulus
· Bloat-Net: A Registry-Based Analysis of Gastric Dilatation-Volvulus (GDV) Risk Factors Including Anatomic Variables
Through this collaborative, the CHF has raised over $300,000 in the Bloat Initiative fund. The above listed Letters of Intent will go under review over the next month. At the end of April, the CHF will notify those applicants that have been selected to submit a full proposal.
Janice moved that the CTMB allocate $25,000 as a Lead Sponsor of the Bloat Initiative from the Donor Advised Fund. Dave seconded. Motion passed unanimously
April 17, 2013 - Study Update
Morris Animal Foundation relies upon the support of animal lovers and partners who believe in our ultimate vision of a world in which animals live long and healthy lives. Thank you for investing in science that will advance veterinary care for animals.
Below is the most recent research update from the principal investigator for the project you are supporting. This condensed update can be shared with donors, members of your organization and anyone interested in animal health.
D10CA-002: Safety and Efficacy of a Novel Anthracycline, AD 198 in Dogs with Refractory Lymphoma, Alfred M. Legendre, DVM
PROGRESS UPDATE: RESULTS: New Drug Not Effective in Treating Dogs with Drug-Resistant Lymphoma
Lymphoma, a type of white blood cell cancer that occurs commonly in dogs, is rarely cured because the cancer becomes resistant to chemotherapy. Doxorubicin, a commonly used chemotherapeutic drug, is very effective, but it can damage the heart, thus limiting the total amount that can be given safely. In recent studies, AD198, a new anthracycline drug that is similar to doxorubicin, showed promise in treating mice with lymphomas that were resistant to doxorubicin without damaging the heart.
Funded by Morris Animal Foundation, researchers from the University of Tennessee tested the safety and effectiveness of AD198 in tissue cultures. In these laboratory tests, the lymphoma cells that were resistant to doxorubicin were also resistant to AD198. This finding is contrary to similar studies done in mice with doxorubicin-resistant lymphomas.
Researchers also concurrently evaluated the effectiveness of AD198 in dogs with resistant lymphoma. Along with other drugs commonly used to treat lymphoma, increasing doses of AD198 were given to dogs with doxorubicin-resistant lymphoma. Similar to the results of the laboratory tissue-culture experiments, canine lymphomas that were resistant to doxorubicin chemotherapy were also resistant to AD198. Given these findings, the researchers do not recommend AD198 as an alternative treatment option for dogs with drug-resistant lymphomas.
Thank you again for investing in Morris Animal Foundation, where science meets hope. Your support of new discoveries and knowledge will make a true difference in the lives of animals—today and tomorrow.
October 30, 2012 - OFA BOARD OF DIRECTORS COMMITS $75,000 IN NEW CANINE HEALTH RESEARCH GRANT FUNDING
Columbia, Missouri, Wednesday, October 31, 2012 - At its Annual Meeting the Orthopedic Foundation for Animals (OFA) Board of Directors approved $75,000 in new canine health research grant sponsorships. The funding will be directed through approved grants at the AKC Canine Health Foundation (AKC CHF) and the Morris Animal Foundation (MAF). Specific research areas include genetic disease mapping studies for cardiomyopathy, subaortic stenosis, cruciate ligament rupture, osteochondritis dissecans, renal dysplasia, cataracts, and urinary stones. The research will be conducted at several of the world's leading academic and research institutions including North Carolina State University, the Broad Institute, the University of Wisconsin, the University of Helsinki, the Animal Health Trust in the UK, Washington State University, and the University of Minnesota.
In addition to regular funding of canine health research grants through the AKC CHF and MAF, as a not-for-profit foundation focused on companion animal health, the OFA contributes regularly through the following programs:
. Through the CHIC DNA Repository, the OFA has underwritten nearly $100,000 in DNA banking expenses involved in DNA sample collections for future canine health research.
Over 16,000 samples have been banked to date, and over 2,000 samples have been provided at no cost to canine health researchers all over the world.
. The OFA's endowed scholarship program at the University Of Missouri College Of Veterinary Medicine supports annual scholarships to deserving veterinary students.
. The OFA funds veterinary student attendance at educational events such as the AKC CHF Biennial National Parent Club Health Conference.
. The OFA's Richard Fox Memorial Fund supports summer research fellowships.
. The OFA's new Eye Certification Registry supports the ACVO Vision for Animals Foundation to support research leading to the elimination of ocular diseases causing vision loss and suffering in animals.
These programs have amounted to over $150,000 in direct support for its mission to improve the health and well being of companion animals through a reduction in the incidence of genetic disease over the last two years, and over $3 million in combined contributions since the OFA's founding in 1966.
For more information please visit the OFA website at www.offa.org
OFA, Columbia, MO
Founded in 1966, the OFA is a not-for-profit foundation with the mission to promote the health and welfare of companion animals through a reduction in the incidence of genetic disease.
This week on Genome Barks, Eddie Dziuk, The Chief Operating Officer of the Orthopedic Foundation for Animals talks with Erika Werne about the Canine Health Information Center. Established in 2001, CHIC is the joint venture between the AKC Canine Health Foundation and OFA that serves as a central database of health information as well as a DNA Repository. At the North Carolina State Breeders' Symposium jointly sponsored by the American Kennel Club and the AKC Canine Health Foundation, Mr. Dziuk discusses the pros and cons of the two methods of DNA collection, exactly how the "recommended tests" become recommended in the first place, as well as the "gold standard" of genetic tests, and how it will impact breeding decisions.